In Madhya Pradesh, a very large area of agricultural and forest land is thickly covered by noxious weed Lantana and the weed is still propagating. As analyzed by the experts Lantana possesses several qualities that could be of immense benefit to humans and animals. Mainly it is said that it can provide shelter to wild animals and plays a significant role in crop protection. Reviled as a nuisance and a menace worldwide, how could a weed is remotely thought of as being environmental friendly? Keeping above fact in mind, extensive survey was conducted in central zone of India during last two years for the assessment and collection of bio-control agents of lantana in the field. 21 species of phytophagous insects have been reported from lantana bushes. Half of the total species collected were Hemiptera, Coleoptera, with Tingidae, Chrysomelidae being the most important family. The present status of biological control of lantana in this region is reviewed together with the prospects of rearing some specific bio-control agents; Spilosoma obliqua and Euproctis subnotana (Walker) and pathogen spp Rhizopus and its effectiveness on lantana. As reported, these specific species are damaging the weed significantly in the field and prove to be a strenuous way for the entire eradication of this obnoxious weed from the environment.