Background: Congenital heart diseases are one of the main causes of death among the congenital malformations. An extracardiac malformation further increases the risk of morbidity and mortality to these patients, in addition to risks of surgical correction. So here comes the importance of extracardiac malformation.

Methods: This prospective observational study was conducted at Department of Pediatrics,Government Medical College Srinagar  The study was conducted over a period of 2 years (from January 2016 to December 2018). Children with congenital heart disease were examined for extracardiac defects.

Results: This hospital based cross-sectional study found that there were 2084 cases of congenital heart diseases among which extracardiac anomalies were present in 416 [19.9%] Out of these n=203[49.1%]were associated with syndromes .Down’s syndrome was commonest found in 112 cases[55.1%]. Multiple congenital defects was seen in n=168[40%] of which musculoskeletal defects were commonest 43.4%.Laterality defect were least common presnt in 45 cases [10.8%].

Conclusions: Association of Congenital heart disease with extracardiac anomalies is well known. Syndromes are most commonly associated.

Emulgel is the most emerging and successful formulation to deliver hydrophobic drugs. When gels and emulsions are used in combined form, the dosage forms are referred as Emulgels. It imbibes the properties of both gel and emulsion which results in enhancing the solubility of the hydrophobic drug to make the drug more bioavailable and enhances the patient compliance as topical drug delivery dosage form. Aceclofenac is NSAID, derivative of diclofenac, used as analgesic and anti-inflammatory agent belongs to BCS class – II drug (low solubility and high permeability) is taken as a drug of choice to formulate as Emulgel. Less dose is sufficient to prepare as topical dosage form. Here, emulgels were prepared as 1% w/w formulation by using carbomer 934 and HPMC K4M separately as gelling agents. Linseed oil as penetration enhancer. Emulgels were prepared and evaluated for rheological properties, pH determination, drug release profiles. The present study reveals that the formulation using carbomer 934 shown better release profile than HPMC K4M which depicts, carbomer 934 is the better choice of polymer to prepare aceclofenac emulgel.